LONGEVITY AND AGE-RELATED PATHOLOGY OF LVG OUTBRED GOLDEN SYRIAN-HAMSTERS (MESOCRICETUS-AURATUS)

被引：8

作者：

DEAMOND, SF

PORTNOY, LG

STRANDBERG, JD

BRUCE, SA

机构：

[1] JOHNS HOPKINS UNIV,SCH HYG & PUBL HLTH,615 N WOLFE ST,BALTIMORE,MD 21205

[2] JOHNS HOPKINS UNIV,SCH MED,DIV COMPARAT MED,BALTIMORE,MD 21205

来源：

EXPERIMENTAL GERONTOLOGY | 1990年 / 25卷 / 05期

关键词：

aging; aging model; amyloidosis; mortality; pathology; Syrian hamster;

D O I：

10.1016/0531-5565(90)90032-W

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

A colony of male Lakeview Golden (LVG) Syrian hamsters has been maintained for the last nine years as a source of various tissues for cellular aging studies. Observations on this colony also yielded data on survival time and physical and pathological manifestations of aging in this strain. Based on 150 spontaneous deaths, the median life span was found to be 19.5 months. The maximum life span was 36 months and the minimum 6 months. A cross-sectional pathological survey of sacrificed and spontaneously dying members of the population revealed a low rate of neoplasia and a variety of degenerative lesions that increased with age. These observations of a varied pathology and a low frequency of neoplasia provide justification for the continued development of the male LVG Syrian hamster as an animal model system for use in studies on the mechanism of both in vivo and in vitro aging. © 1990.

引用

页码：433 / 446

页数：14

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