RETENTION OF NEUTRAL AND BASIC HETEROAROMATIC HYDROCARBONS IN RPLC SYSTEMS AND ITS USE IN PREDICTIVE STUDIES .1. CONCENTRATION OF THE ORGANIC MODIFIER

被引:8
作者
DEVOOGT, P
WEGENER, JWM
BRINKMAN, UAT
GOVERS, H
机构
[1] FREE UNIV AMSTERDAM,INST ENVIRONM STUDIES,1007 MC AMSTERDAM,NETHERLANDS
[2] FREE UNIV AMSTERDAM,DEPT ANALYT CHEM,ENVIRONM CHEM SECT,1081 HV AMSTERDAM,NETHERLANDS
[3] UNIV AMSTERDAM,ENVIRONM TOXICOL & CHEM LAB,1018 WV AMSTERDAM,NETHERLANDS
关键词
D O I
10.1016/0048-9697(91)90171-A
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The retention of polynuclear heteroaromatic hydrocarbons in reversed-phase liquid chromatographic systems was studied using methanol-water or acetonitrile-water as the mobile phase. The relation between the concentration of the modifier and the capacity factor was investigated, and capacity factors in pure water were obtained by means of extrapolation of this relation and were used in quantitative chromatographic retention-activity relationships. It was shown that the general equation for the relationship between the n-octanol/water partition coefficient (log K(ow)) and retention of apolar compounds in octadecyl-silica/methanol-water systems, first presented by Tomlinson and Hafkenscheid, is valid for neutral heteroaromatic hydrocarbons. For basic heteroaromatic compounds, this relationship is not valid. Both log K(ow) and the logarithm of the bioconcentration factor in the guppy (Poecilia reticulata) of neutral heteroaromatic hydrocarbons can be predicted satisfactorily from capacity factors extrapolated to pure water.
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页码:69 / 87
页数:19
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