VARIATION IN COURSE OF HEPATITIS-E IN EXPERIMENTALLY INFECTED CYNOMOLOGUS MONKEYS

被引:71
作者
TSAREV, SA
EMERSON, SU
TSAREVA, TS
YARBOUGH, PO
LEWIS, M
GOVINDARAJAN, S
REYES, GR
SHAPIRO, M
PURCELL, RH
机构
[1] BIOQUAL INC,ROCKVILLE,MD
[2] GENELABS INC,DEPT MOLEC VIROL,REDWOOD CITY,CA
[3] RANCHO LOS AMIGOS MED CTR,PATHOL & CLIN LABS,DOWNEY,CA 90242
关键词
D O I
10.1093/infdis/167.6.1302
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Five cynomolgus monkeys (Macaca fascicularis) developed hepatitis after inoculation with a prototype strain of hepatitis E virus (HEV) from Pakistan. Although all 5 monkeys displayed liver enzyme elevations, viremia, virus secretion in feces, and seroconversion, two different patterns of these parameters were observed. For 4 monkeys, increased alanine aminotransferase (ALT) activity was first observed on days 21-26, viremia occurred before and during enzyme elevation, and the animals seroconverted coincidentally with the end of viremia or shortly thereafter. One of these monkeys had a more severe hepatitis, with peak ALT values more than twice the peak levels of the other monkeys. The fifth monkey developed biphasic hepatitis with peaks of ALT activity on days 26 and 54. In this case, viremia and seroconversion were correlated only with the second peak of enzyme elevation and liver histopathology only with the first peak. Viral shedding in this fifth animal lasted two times longer than in other animals.
引用
收藏
页码:1302 / 1306
页数:5
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