CROMOLYN VERSUS NEDOCROMIL - DURATION OF ACTION IN EXERCISE-INDUCED ASTHMA IN CHILDREN

被引：30

作者：

DEBENEDICTIS, FM ^{[1
]}

TUTERI, G ^{[1
]}

PAZZELLI, P ^{[1
]}

BERTOTTO, A ^{[1
]}

BRUNI, L ^{[1
]}

VACCARO, R ^{[1
]}

机构：

[1] UNIV PERUGIA, CHILDRENS HOSP, I-06100 PERUGIA, ITALY

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 1995年 / 96卷 / 04期

关键词：

EXERCISE-INDUCED ASTHMA; CROMOLYN SODIUM; NEDOCROMIL SODIUM; CHILDREN;

D O I：

10.1016/S0091-6749(95)70295-4

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Cromolyn sodium (10 mg), nedocromil sodium (4 mg), and placebo, all delivered by a metered dose inhaler, were compared in their efficacy and duration of action in preventing exercise-induced asthma in children. After a screening test was performed, 13 patients with asthma performed standard exercise texts 20 minutes and 140 minutes after drug inhalation in a randomized, double-blind, crossover study. Both drugs were significantly more protective than placebo after 20 minutes, but no significant difference between active drugs and placebo was found 140 minutes after inhalation. At these clinically recommended doses both cromolyn sodium and nedocromil sodium provide equal protection against exercise-induced asthma, and the duration of action of both lasts for less than 2 hours.

引用

页码：510 / 514

页数：5

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