REGULATION OF CHOLESTEROL-SYNTHESIS IN SKIN FIBROBLASTS DERIVED FROM OLD-PEOPLE

被引：8

作者：

SHAKESPEARE, V ^{[1
]}

POSTLE, AD ^{[1
]}

机构：

[1] UNIV SOUTHAMPTON,CHILD HLTH UNIT,SOUTHAMPTON SO9 3TU,HAMPSHIRE,ENGLAND

来源：

ATHEROSCLEROSIS | 1979年 / 33卷 / 03期

关键词：

Ageing; Cholesterol; Fibroblasts;

D O I：

10.1016/0021-9150(79)90187-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sterol synthesis from radioactive acetate and the suppression of this synthesis by human low density lipoprotein (LDL) have been investigated in skin fibroblast strains derived from infant donors and from donors over the age of 70 years. The activity of the enzyme hydroxymethylglutaryl-CoA reductase and its repression by LDL has also been investigated in these fibroblast strains and in senescent cells of the foetal lung cell strain MRC-5. No age-related differences could be detected either in repression of [3H]acetate incorporation by LDL, or in repression of HMG-CoA reductase activity. © 1979.

引用

页码：359 / 364

页数：6

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