THE PROTECTIVE ROLE OF POLYPHENOLS IN CYTOTOXICITY OF HYDROGEN-PEROXIDE

被引：35

作者：

NAKAYAMA, T

NIIMI, T

OSAWA, T

KAWAKISHI, S

机构：

[1] Department of Food Science and Technology, Faculty of Agricuhure, Nagoya University, Chikusa, Nagoya

来源：

MUTATION RESEARCH | 1992年 / 281卷 / 02期

关键词：

HYDROGEN PEROXIDE; POLYPHENOL; ANTIOXIDANT; ACTIVE OXYGEN SPECIES;

D O I：

10.1016/0165-7992(92)90039-K

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A variety of synthetic and natural polyphenols protect mammalian cells from hydrogen peroxide (H2O2). Cytotoxicity of H2O2 on Chinese hamster V79 cells was assessed with a colony formation assay, and several polyphenols prevented the decrease in the number of colonies caused by H2O2. A study of the structure-activity relationship revealed that affinity of the polyphenols for the cell membrane and the presence of an ortho-dihydroxy moiety in their structure proved essential to this protection.

引用

页码：77 / 80

页数：4

共 7 条

[1] CALCIUM CHELATOR QUIN-2 PREVENTS HYDROGEN-PEROXIDE-INDUCED DNA BREAKAGE AND CYTO-TOXICITY [J].