BIO-FIELD-EFFECT TRANSISTORS FOR PROCESS-CONTROL IN BIOTECHNOLOGY

被引：20

作者：

BRAND, U

REINHARDT, B

RUTHER, F

SCHEPER, T

SCHUGERL, K

机构：

[1] Institut für Technische Chemie, Universität Hannover, D-3000 Hannover 1

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 1991年 / 4卷 / 3-4期

关键词：

D O I：

10.1016/0925-4005(91)80129-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The application of enzyme-modified field-effect transistors (BioFETs) in biotechnological process control is presented. Penicillin, glucose and urea are detected with these devices in cultivation media and on-line in biotechnological processes. In these applications, the BioFETs are used as detectors in flow injection analysis (FIA) systems. Special flow cells with a small volume, constructed for this purpose, guarantee an optimum sample transport to the sensor. Therefore, 15-20 determinations per hour can be performed. The BioFET/FIA system gives good results for the on-line monitoring of glucose and urea during cultivations of S.cerevisiae and E.coli in different types of bioreactors.

引用

页码：315 / 318

页数：4