NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCE OF PORCINE INTERLEUKIN 4 CDNA DERIVED FROM LAMINA PROPRIA LYMPHOCYTES

被引:17
作者
BAILEY, M [1 ]
PERRY, ACF [1 ]
BLAND, PW [1 ]
STOKES, CR [1 ]
HALL, L [1 ]
机构
[1] UNIV BRISTOL,DEPT BIOCHEM,BRISTOL BS8 1TH,AVON,ENGLAND
关键词
INTERLEUKIN-4; CYTOKINE; LYMPHOCYTE; INTESTINE; (PIG);
D O I
10.1016/0167-4781(93)90077-Q
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Total RNA was isolated from in vitro activated lamina propria lymphocytes and used to direct the synthesis of cDNA. Interleukin 4 transcripts were then specifically amplified by PCR. Comparison of the nucleotide sequence with its human homologue demonstrates deletion within the coding region of pig interleukin 4 centred around amino acid residue 70 in the mature human protein.
引用
收藏
页码:328 / 330
页数:3
相关论文
共 20 条
  • [1] INTERLEUKIN-2, INTERLEUKIN-4 AND INTERLEUKIN-5 ARE SEQUENTIALLY PRODUCED IN MITOGEN-STIMULATED MURINE SPLEEN-CELL CULTURES
    CARDELL, S
    SANDER, B
    [J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (02) : 389 - 395
  • [2] COFFMAN RL, 1986, J IMMUNOL, V136, P4538
  • [3] REGULATION OF MURINE LYMPHOKINE PRODUCTION INVIVO .3. THE LYMPHOID-TISSUE MICROENVIRONMENT EXERTS REGULATORY INFLUENCES OVER T-HELPER CELL-FUNCTION
    DAYNES, RA
    ARANEO, BA
    DOWELL, TA
    HUANG, K
    DUDLEY, D
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (04) : 979 - 996
  • [4] CDNA CLONING OF PORCINE INTERLEUKIN-2 BY POLYMERASE CHAIN-REACTION
    GOODALL, JC
    EMERY, DC
    BAILEY, M
    ENGLISH, LS
    HALL, L
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1991, 1089 (02) : 257 - 258
  • [5] RECIPROCAL EXPRESSION OF INTERFERON-GAMMA OR INTERLEUKIN-4 DURING THE RESOLUTION OR PROGRESSION OF MURINE LEISHMANIASIS - EVIDENCE FOR EXPANSION OF DISTINCT HELPER T-CELL SUBSETS
    HEINZEL, FP
    SADICK, MD
    HOLADAY, BJ
    COFFMAN, RL
    LOCKSLEY, RM
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (01) : 59 - 72
  • [6] CLONING OF A FULL-LENGTH CDNA-ENCODING BOVINE INTERLEUKIN-4 BY THE POLYMERASE CHAIN-REACTION
    HEUSSLER, VT
    EICHHORN, M
    DOBBELAERE, DAE
    [J]. GENE, 1992, 114 (02) : 273 - 278
  • [7] IDENTIFICATION OF A T-CELL-DERIVED B-CELL GROWTH-FACTOR DISTINCT FROM INTERLEUKIN-2
    HOWARD, M
    FARRAR, J
    HILFIKER, M
    JOHNSON, B
    TAKATSU, K
    HAMAOKA, T
    PAUL, WE
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 155 (03) : 914 - 923
  • [8] T-CELL-DERIVED B-CELL DIFFERENTIATION FACTOR(S) - EFFECT ON THE ISOTYPE SWITCH OF MURINE B-CELLS
    ISAKSON, PC
    PURE, E
    VITETTA, ES
    KRAMMER, PH
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1982, 155 (03) : 734 - 748
  • [9] JAMES SP, 1990, J IMMUNOL, V144, P1251
  • [10] CONVERSION OF HUMAN INTERLEUKIN-4 INTO A HIGH-AFFINITY ANTAGONIST BY A SINGLE AMINO-ACID REPLACEMENT
    KRUSE, N
    TONY, HP
    SEBALD, W
    [J]. EMBO JOURNAL, 1992, 11 (09) : 3237 - 3244