NEUROKININ AGONISTS DIFFERENTIALLY AFFECT A9-DOPAMINE AND A10-DOPAMINE CELLS IN THE RAT

被引：58

作者：

OVERTON, P

ELLIOTT, PJ

HAGAN, RM

CLARK, D

机构：

[1] UNIV READING,DEPT PSYCHOL,NEUROPSYCHOPHARMACOL LAB,EARLY GATE,READING RG6 2AL,BERKS,ENGLAND

[2] GLAXO GRP RES LTD,DEPT NEUROPHARMACOL,WARE SG12 0DP,HERTS,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 213卷 / 01期

关键词：

DOPAMINE CELLS; EXTRACELLULAR RECORDING; NEUROKININ RECEPTORS;

D O I：

10.1016/0014-2999(92)90251-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of selective neurokinin (NK) receptor agonists on the activity of A9 and A10 dopamine cells was assessed using extracellular recording. A higher proportion of A10 cells which were administered the NK1 receptor agonist GR73632 or the NK3 receptor agonist senktide showed an effect, whereas the NK2 receptor agonist GR64349 did not discriminate as clearly between the two cell groups. The most frequently encountered response in all cases was an increase in firing rate.

引用

页码：165 / 166

页数：2

共 5 条

[1] BEHAVIORAL AND BIOCHEMICAL RESPONSES FOLLOWING ACTIVATION OF MIDBRAIN DOPAMINE PATHWAYS BY RECEPTOR SELECTIVE NEUROKININ AGONISTS [J].