SCHISTOSOMA-JAPONICUM-INFECTED MICE SHOW REDUCED HEPATIC-FIBROSIS AND EOSINOPHILIA AND SELECTIVE-INHIBITION OF INTERLEUKIN-5 SECRETION BY CD4+- CELLS AFTER TREATMENT WITH ANTI-INTERLEUKIN-2 ANTIBODIES

被引：13

作者：

CHEEVER, AW ^{[1
]}

XU, YH ^{[1
]}

SHER, A ^{[1
]}

FINKELMAN, FD ^{[1
]}

COX, TM ^{[1
]}

MACEDONIA, JG ^{[1
]}

机构：

[1] UNIFORMED SERV UNIV HLTH SCI,F EDWARD HEBERT SCH MED,DEPT MED,BETHESDA,MD 20814

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 04期

关键词：

D O I：

10.1128/IAI.61.4.1288-1292.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Schistosoma japonicum-infected mice were injected with antibodies to interleukin-2 (IL-2) and/or IL-2 receptor to clarify the role of IL-2 on the granulomatous reaction around schistosome eggs in the liver. Granulomas were of normal or slightly increased size in animals subjected to IL-2 blockade, but hepatic fibrosis was markedly decreased in treated animals 10 weeks after infection. Anti-IL-2 treatment significantly decreased the in vitro secretion of IL-5 by antigen-stimulated spleen cells, and peripheral eosinophilia and tissue eosinophilia were diminished. Secretion of IL-2, IL-4, and gamma interferon was unaffected. Our results indicate that IL-2 is not an essential determinant of granuloma size in S. japonicum-infected mice but that, as in Schistosoma mansoni infection, the development of hepatic fibrosis is critically dependent on IL-2 levels and granuloma size and hepatic fibrosis are differentially regulated.

引用

页码：1288 / 1292

页数：5

共 24 条

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