PREVENTION AND TREATMENT OF OCULAR INFLAMMATION WITH A NEW CLASS OF NONSTEROIDAL ANTIINFLAMMATORY AGENTS

被引：19

作者：

CHIOU, GCY

YAO, QS

CHANG, MS

OKAWARA, T

机构：

[1] Institute of Ocular Pharmacology, Department of Medical Pharmacology and Toxicology, Texas A&M University Health Science Center, College Station, Texas

[2] Faculty of Pharmaceutical Sciences, Kumamoto University, Kumamoto

来源：

JOURNAL OF OCULAR PHARMACOLOGY | 1994年 / 10卷 / 01期

关键词：

D O I：

10.1089/jop.1994.10.335

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

New non-steroidal anti-inflammatory agents (NSAIAs) were tested on lens protein-, endotoxin- and interleukin-1-induced ocular inflammation. It was found that most NSAIAs, including REV 5901, mefenamic acid, indomethacin, CK-17 and CK-102, inhibited lens protein-induced inflammation. Endotoxin induced inflammation indirectly through the release of IL-1 which was inhibited by fewer agents, including CK-17, CK-102 and prednisolone. However, the direct effect of IL-1 can only be suppressed by CK-17 and prednisolone. Therefore, CK-17 could become an important NSAIA which acts similarly to corticosteroids yet produces no steroidal side effects. CK-17 was different from most NSAIAs as it affected little, if any, arachidonate metabolism. Most importantly, CK-17 was found to be 2-fold more potent than prednisolone in inhibiting IL-1-induced uveitis, while no side effects were noted at doses tested to date.

引用

页码：335 / 347

页数：13

共 17 条

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