COMPARATIVE EFFECTS OF HALOTHANE, ENFLURANE, ISOFLURANE AND SEVOFLURANE ON FUNCTION AND METABOLISM IN THE ISCHEMIC RAT-HEART

被引：47

作者：

OGUCHI, T

KASHIMOTO, S

YAMAGUCHI, T

NAKAMURA, T

KUMAZAWA, T

机构：

[1] Department of Anaesthesiology, Yamanashi Medical University, Nakakoma-gun, Yamanashi 409-38, Shimokato 1110, Tamaho-cho

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1995年 / 74卷 / 05期

关键词：

ANESTHETICS VOLATILE; HALOTHANE; ENFLURANE; ISOFLURANE; SEVOFLURANE; HEART; ISCHEMIA; ISOLATED PREPARATION; RAT;

D O I：

10.1093/bja/74.5.569

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

This study was designed to examine the effects of inhalation anaesthetics on function and metabolism in isolated ischaemic rat hearts. Four volatile anaesthetics in two different concentrations (1.0 to 1.5 MAC) were used before whale heart ischaemia was induced for 15 min followed by reperfusion for 30 min. The data were compared with a control group in which inhalation anaesthetics were not used. Before ischaemia, volatile anaesthetics depressed ventricular function. During reperfusion, ventricular function and coronary flow in both halothane groups were significantly lower than those in the control group. Myocardial ATP concentrations in the 1.0 MAC of enflurane and isoflurane groups were significantly higher than those in the control group. We conclude that halothane had more depressant effects than the other anaesthetics and that enflurane and isoflurane may enhance metabolic recovery in the ischaemic working rat heart.

引用

页码：569 / 575

页数：7

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