THE HUMAN ERYTHROCYTE-MEMBRANE CONTAINS A NOVEL 12-KDA INOSITOLPHOSPHATE-BINDING PROTEIN THAT IS AN IMMUNOPHILIN

被引：9

作者：

CUNNINGHAM, EB

机构：

[1] Univ Med and Dent New Jersey, New Jersey Med Sch, Dept Biochem and Molec Biol, Newark

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 215卷 / 01期

关键词：

D O I：

10.1006/bbrc.1995.2455

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 12-kDa inositolphosphate-binding protein has been identified as a component of the human erythrocyte membrane. Its robust peptidylprolyl cis-trans isomerase activity that is strongly inhibited by the immunosuppressant drugs FK506 and rapamycin indicates that it is an immunophilin belonging to the FKBP class. The finding that its peptidylprolyl cis-trans isomerase activity is also strongly inhibited by nanomolar concentrations of the second messengers inositol 1,4,5-trisphosphate (IP3) and inositol 1,3,4,5-tetrakisphosphate (IP4,) suggests that IP3, and IP4, could be physiological ligands for this membrane-associated immunophilin. (C) 1995 Academic Press, Inc.

引用

页码：212 / 218

页数：7

共 25 条

[1]

ALNEMRI ES, 1994, J BIOL CHEM, V269, P30828

[2] INOSITOL PHOSPHATES AND CELL SIGNALING [J].