BISMURRAYAQUINONE-A - SYNTHESIS, CHROMATOGRAPHIC ENANTIOMER RESOLUTION, AND STEREOANALYSIS BY COMPUTATIONAL AND EXPERIMENTAL CD INVESTIGATIONS

被引:46
作者
BRINGMANN, G
LEDERMANN, A
STAHL, M
GULDEN, KP
机构
[1] Institut für Organische Chemie, Universität Würzburg, 97074 Würzburg, Am Hubland
关键词
D O I
10.1016/0040-4020(95)00528-G
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The first total synthesis of a naturally occurring dimeric carbazole alkaloid, bismurrayaquinone A (4), is described, by oxidation of dimeric O-demethylmurrayafoline A, a still hypothetic natural product recently synthesized. By chromatography on a chiral phase, the two atropoenantiomers were separated. The absolute configurations of these two rotational isomers were elucidated by comparison of their calculated spectra with those measured experimentally.
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页码:9353 / 9360
页数:8
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