A CARBOXYLESTERASE FROM THE PARASITIC NEMATODE ASCARIS-SUUM HOMOLOGOUS TO THE INTESTINAL-SPECIFIC GES-1 ESTERASE OF CAENORHABDITIS-ELEGANS

被引：1

作者：

AZZARIA, M

HENZEL, WJ

MCGHEE, JD

机构：

[1] UNIV CALGARY, DEPT MED BIOCHEM, CALGARY, AB T2N 4N1, CANADA

[2] GENENTECH INC, S SAN FRANCISCO, CA 94080 USA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1994年 / 109卷 / 2-3期

基金：

英国医学研究理事会;

关键词：

ASCARIS SUUM; NEMATODE; GES-1; ESTERASE; CAENORHABDITIS ELEGANS;

D O I：

10.1016/0305-0491(94)90006-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified a carboxylesterase in A. suum that appears to be the homolog of the gut-specific C. elegans ges-1 enzyme. The A. suum esterase was purified and its N-terminal sequence found to be 50% identical to the C. elegans ges-1 protein. We have used isoelectric focusing analysis to demonstrate that, unlike the C. elegans ges-1 esterase, the A. suum enzyme is not restricted to the gut but is expressed in a wide range of tissues.

引用

页码：225 / 236

页数：12

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