TUMOR LYSIS SYNDROME - PATHOGENESIS AND MANAGEMENT

被引：132

作者：

JONES, DP

MAHMOUD, H

CHESNEY, RW

机构：

[1] Department of Pediatrics, University of Tennessee, Memphis, LeBonheur Children's Medical Center, Memphis, 38103, Tennessee, 50 North Dunlap

[2] Center for Pediatric Pharmacokinetics and Therapeutics, Pediatric Pharmacology Research Unit, Crippled Children's Research Foundation, Memphis, Tennessee

[3] Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee

来源：

PEDIATRIC NEPHROLOGY | 1995年 / 9卷 / 02期

关键词：

TUMOR LYSIS SYNDROME; ACUTE RENAL FAILURE; HYPERPHOSPHATEMIA; HYPERURICEMIA; DIALYSIS; HEMOFILTRATION;

D O I：

10.1007/BF00860751

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Tumor lysis syndrome refers to the metabolic disturbances. (hyperuricemia, hyperphosphatemia, hyperkalemia, and hypocalcemia) associated with lymphoproliferative malignancies which occur secondary to cell lysis. In some patients, tumor lysis results in acute renal failure. The nature and severity of the metabolic alterations are variable and may be influenced by the timing and intensity of chemotherapy, the magnitude of cell lysis, and the general condition of the patient with respect to hydration and glomerular filtration rate. Not only do hyperuricemia and hyperphosphatemia result from tumor lysis syndrome, they also contribute to oliguric acute renal failure in patients with tumor lysis. The pathogenesis of tumor lysis syndrome and current therapeutic strategies are discussed.

引用

页码：206 / 212

页数：7

共 29 条

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