PROTOCOLLAGEN PROLINE HYDROXYLASE ACTIVITY IN SKIN OF NORMAL HUMAN SUBJECTS AND OF PATIENTS WITH SCLERODERMA

被引：93

作者：

UITTO, J

HALME, J

HANNUKSELA, M

PELTOKALLIO, P

KIVIRIKKO, KI

机构：

[1] Children's Hospital, Department of Medical Chemistry, Department of Dermatology, and Second Surgical Department, University of Helsinki, Helsinki

来源：

SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 1969年 / 23卷 / 03期

关键词：

Collagen; Hydroxyproline; Protocollagen; Protocollagen hydroxylase; Protocollagen proline hydroxylase; Scleroderma; Skin; human;

D O I：

10.3109/00365516909077656

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The activity of parotocollagen proline hydroxylase was assayed in punch biopsy specimens of human skin. The enzyme in human skin was similar to that from animal sources, in that it was recovered in the soluble protein fraction and in that it required atmospheric oxygen, ascorbate, αketoglutarate and ferrous iron. The activity of protocollagen proline hydroxylase was highest in foetuses and newborn infants, and decreased with advancing age. A slight elevation of the enzyme activity was found in three out of five patients with actively progressing scleroderma. © 1969 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：241 / +

页数：1

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