COMPARATIVE BIOAVAILABILITY OF CARBAMAZEPINE IN 100 MG AND 200 MG TABLETS

被引：4

作者：

SMITH, GA

HOOPER, WD

TYRER, JH

EADIE, MJ

WERTH, B

机构：

[1] UNIV QUEENSLAND, ROYAL BRISBANE HOSP, DEPT MED, BRISBANE 5000, Qld, AUSTRALIA

[2] CIBA GEIGY AUSTRALIA LTD, SYDNEY, AUSTRALIA

来源：

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1979年 / 6卷 / 01期

关键词：

bioavailability; carbamazepine; pharmacokinetics;

D O I：

10.1111/j.1440-1681.1979.tb00005.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The bioavailabilities of carbamazepine in 100 mg and 200 mg tablets have been compared in a cross‐over study of six subjects after two 600 mg doses of the drug, the different preparations being taken at 3 week intervals. 2. Areas under the plasma level curves, absorption rate constants and times to achieve peak plasma levels showed little difference between the two preparations. These findings suggest similar rates and extents of bioavailability of carbamazepine in the two preparations. 3. Calculated mean absorption and elimination parameters for carbamazepine were as follows: kabδ= 0.1081 h‐1, (s.d. = 0.0289); Tmax= 23.39 h, (s.d. = 8.66); K: = 0.0191 h‐1, (s.d. = 0.0033); VD= 0.989 1/kg, (s.d. = 0.159); and clearance = 0.0185 1/kgh, (s.d. = 0.0015). Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：37 / 40

页数：4

共 5 条

[1] PHARMACOKINETICS OF CARBAMAZEPINE [J].