ALKYLATIONS AND ACYLATIONS OF ALPHA-ARYL-4-MORPHOLINEACETONITRILES (MASKED ACYL ANION EQUIVALENTS) AND THEIR USE IN 1,4-ADDITIONS

被引：45

作者：

MCEVOY, FJ ^{[1
]}

ALBRIGHT, JD ^{[1
]}

机构：

[1] AMER CYANAMID CO,LEDERLE LABS,DIV MED RES,PEARL RIVER,NY 10965

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 25期

关键词：

D O I：

10.1021/jo00393a030

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The anions of α-aryl-4-morpholineacetonitriles are alkylated with ethyl bromoacetate, epichlorohydrin, or allyl chloride and displace halogen on benzene derivatives containing electron-withdrawing groups to give benzophenones. These anions are acylated with ethyl chloroformate and benzoyl chlorides and add to ethyl acrylate and acrylonitrile to give good yields of 1, 4-addition products. © 1979, American Chemical Society. All rights reserved.

引用

页码：4597 / 4603

页数：7

共 30 条

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