RECURRENT CHROMOSOMAL-ABERRATIONS IN NON-HODGKIN AND NON-BURKITT LYMPHOMAS

Eleven non-Hodgkin and non-Burkitt type lymphomas were studied in direct preparations with banding techniques. The results from these experiments and those from 13 cases reported earlier were surveyed, together with data from 64 additional cases from the literature. A great number of recurrent deviations, particularly structural ones, were revealed: 1) A 14q+ marker was found in 45% of the cases; the extra material was derived from 11 different chromosome types (usually from their long arms) and translocated onto No. 14 at q32; Nos. 1, 8, 10, 11, 14, and 18 were involved as donor chromosome more than once, i.e., in 5, 5, 2, 6, 3, and 5 cases, respectively; for each recurrent donor chromosome the same, or almost the same, segment was translocated in different cases. 2) A 6q- marker with break points in q21 - 23 or q13 - 15 was observed in up to one-quarter of the lymphomas. 3) Other common recurrent marker chromosomes were 1q-, 11q-, 1q-, 9q-, 18q-, 3p-, and 8q-. 4) A gain of one No. 3 was a frequent, and often early, change in abnormal stem lines; other common numerical deviations were gains of Nos. 7 and 18 and losses of Nos. 8 and 15. It is hypothesized that the distribution and characteristics of recurrent deviations, particularly structural ones, are programmed" by genic changes related to cell differentiation. © 1979."