26-HYDROXYSQUALENE AND DERIVATIVES - SUBSTRATES AND INHIBITORS FOR SQUALENE EPOXIDASE

被引：13

作者：

BAI, M

XIAO, XY

PRESTWICH, GD

机构：

[1] Department of Chemistry State, University of New York Stoney Brook

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(00)80258-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

26-Hydroxysqualene (26-HS) was synthesized from squalene and shown to be a potent competitive inhibitor (K(l) = 4-mu-M) of partially-purified pig liver squalene epoxidase (SE). The corresponding aldehyde, amine and diazoacetate derivatives were also evaluated as SE inhibitors. The [H-3]26-HS was converted to a mixture of regioisomeric 2,3-epoxides bearing either a 26-hydroxyl or a 29-hydroxyl group.

引用

页码：227 / 232

页数：6

共 16 条

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