ZINC PYRAZOLYLBORATE COMPLEXES RELEVANT TO THE BIOLOGICAL FUNCTION OF CARBONIC-ANHYDRASE

被引：118

作者：

LOONEY, A

PARKIN, G

ALSFASSER, R

RUF, M

VAHRENKAMP, H

机构：

[1] COLUMBIA UNIV,DEPT CHEM,NEW YORK,NY 10027

[2] UNIV FREIBURG,INST ANORGAN & ANALYT CHEM,W-7800 FREIBURG,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1992年 / 31卷 / 01期

关键词：

D O I：

10.1002/anie.199200921

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The structure and function of the active center of the zinc enzyme carboanhydrase-the biological counterpart to hemoglobin, which transports CO2 from the body-are quite well known, though none of the postulated intermediates of the catalytic cycle has been characterized. With the labile hydrogencarbonato complex 1, formed from the analogous hydroxo complex by the reversible uptake of CO2, a model compound for one of the key steps in the catalytic cycle is now obtained for the first time.

引用

页码：92 / 93

页数：2

共 22 条

[1] A MONONUCLEAR ZINC HYDROXIDE COMPLEX STABILIZED BY A HIGHLY SUBSTITUTED TRIS(PYRAZOLY)HYDROBORATO LIGAND - ANALOGIES WITH THE ENZYME CARBONIC-ANHYDRASE
ALSFASSER, R
TROFIMENKO, S
LOONEY, A
PARKIN, G
VAHRENKAMP, H
[J]. INORGANIC CHEMISTRY, 1991, 30 (21) : 4098 - 4100
[2] Bertini I., 1986, ZINC ENZYMES
[3] BROWN RS, 1983, ZINC ENZYMES, P55
[4] CHEMICAL-REACTIONS OF SULFONAMIDES WITH CARBONIC-ANHYDRASE
COLEMAN, JE
[J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1975, 15 : 221 - 242
[5] CRYSTALLOGRAPHIC STUDIES OF INHIBITOR BINDING-SITES IN HUMAN CARBONIC ANHYDRASE-II - A PENTA-COORDINATED BINDING OF THE SCN- ION TO THE ZINC AT HIGH PH
ERIKSSON, AE
KYLSTEN, PM
JONES, TA
LILJAS, A
[J]. PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1988, 4 (04): : 283 - 293
[6] Eriksson E. A., 1986, ZINC ENZYMES, P317
[7] EVIDENCE FOR DIRECT METAL-NITROGEN BINDING IN AROMATIC SULFONAMIDE COMPLEXES OF CADMIUM(II)-SUBSTITUTED CARBONIC-ANHYDRASES BY CD-113 NUCLEAR MAGNETIC-RESONANCE
EVELHOCH, JL
BOCIAN, DF
SUDMEIER, JL
[J]. BIOCHEMISTRY, 1981, 20 (17) : 4951 - 4954
[8] GALDES A, 1983, ZINC ITS ROLE BIOL N, P1
[9] TRIS(3-TERT-BUTYLPYRAZOLYL)HYDROBORATO ZINC HYDRIDE - SYNTHESIS, STRUCTURE AND REACTIVITY OF A MONOMERIC ZINC HYDRIDE DERIVATIVE
HAN, R
GORRELL, IB
LOONEY, AG
PARKIN, G
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1991, (10) : 717 - 719
[10] AN ABINITIO STUDY OF TRANSITION STRUCTURES AND ASSOCIATED PRODUCTS IN [ZNOHCO2]+, [ZNHCO3H2O]+, AND [ZN(NH3)3HCO3]+ HYPERSURFACES - ON THE ROLE OF ZINC IN THE CATALYTIC MECHANISM OF CARBONIC-ANHYDRASE
JACOB, O
CARDENAS, R
TAPIA, O
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (24) : 8692 - 8705

← 1 2 3 →