EFFECT OF SOFT SEGMENT CHEMISTRY ON THE BIOSTABILITY OF SEGMENTED POLYURETHANES .2. INVITRO HYDROLYTIC DEGRADATION AND LIPID SORPTION

被引：71

作者：

TAKAHARA, A ^{[1
]}

HERGENROTHER, RW ^{[1
]}

COURY, AJ ^{[1
]}

COOPER, SL ^{[1
]}

机构：

[1] UNIV WISCONSIN, DEPT CHEM ENGN, 1415 JOHNSON DR, MADISON, WI 53706 USA

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH | 1992年 / 26卷 / 06期

关键词：

D O I：

10.1002/jbm.820260609

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

A series of segmented polyurethanes (SPUs) with various polyol soft segments was prepared and their hydrolytic degradation and degradation due to lipid sorption was investigated. The hydrolytic degradation of the SPUs was investigated in a papain solution, where it was shown that the SPU based on poly(ethyleneoxide) (PEO) soft segment was susceptible to hydrolytic degradation. X-ray photoelectron spectroscopic (XPS) data suggest dissociation of the urethane linkage by enzymatic degradation. Degradation by lipid sorption was observed for the SPU based on a poly(dimethylsiloxane) (PDMS) soft segment. This is ascribed to the high solubility of lipid in the PDMS segment of the SPU.

引用

页码：801 / 818

页数：18

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