DETERMINATION OF 3-CHLOROPROPANEDIOL AND RELATED DIOXOLANES BY GAS-CHROMATOGRAPHY

3-Chloropropanediol has been derivatized with N,O-bis(trimethylsilyl)trifluoroacetamide and determined by capillary gas chromatography in extracts of resins and in solvents containing ketones and the corresponding ketals (dioxolanes). n-Tetradecane was used as the internal standard. Underivatized 3-chloropropanediol reacts with ketones and forms the corresponding ketals (dioxolanes). Ketones interfere therefore with the determination of underivatized 3-chloropropanediol. The reaction between 3-chloropropanediol and acetone in excess obeys pseudo-first-order kinetics. The precision of gas chromatography, expressed as the standard deviation, was found to be 0.43-mu-g/ml or (relative standard deviation) 0.42%.