PARENCHYMAL STABILITY

被引:30
作者
STAMENOVIC, D
WILSON, TA
机构
[1] UNIV MINNESOTA, DEPT AEROSP ENGN & MECH, 107 ACKERMAN HALL, 110 UNION ST SE, MINNEAPOLIS, MN 55455 USA
[2] BOSTON UNIV, DEPT BIOMED ENGN, BOSTON, MA 02215 USA
关键词
MODELING; MECHANICS; ATELECTASIS;
D O I
10.1152/jappl.1992.73.2.596
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Both continuum and micromechanical models have been used to describe the mechanics of lung parenchyma. Different authors, using different models, have come to different conclusions about parenchymal stability. We show that the continuum model, augmented by bounds on the elastic moduli obtained from recent micromechanical modeling, yields the same conclusions about stability that have been obtained from purely micromechanical modeling: if the lung were homogeneous, it would be stable; local atelectasis would not occur at positive transpulmonary pressure. However, the same analysis yields the prediction that if the surface-to-volume ratio is not uniform throughout the lung, regions of higher surface density collapse if surface tension is large and insensitive to surface area. A micromechanical model that illustrates regional collapse is described.
引用
收藏
页码:596 / 602
页数:7
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