MOBILIZATION OF THE PENICILLINASE GENE IN ENTEROCOCCUS-FAECALIS

被引：5

作者：

CHOW, JW

PERRI, MB

THAL, LA

ZERVOS, MJ

机构：

[1] WAYNE STATE UNIV,SCH MED,DEPT MED,DIV INFECT DIS,DETROIT,MI 48201

[2] WILLIAM BEAUMONT HOSP,SECT INFECT DIS,ROYAL OAK,MI 48073

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 05期

关键词：

D O I：

10.1128/AAC.37.5.1187

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Enterococcus faecalis SF4855 is a beta-lactamase-producing isolate resistant to high levels of gentamicin, with determinants for these resistances on the chromosome. SF4855 transferred both determinants into E. faecalis FA2-2 and UV202 at a frequency of 10(-9) in the presence of the MLS plasmid pYN120. Beta-Lactamase and gentamicin resistance probes hybridized to three locations on the chromosome of FA2-2 transconjugants on contour-clamped homogeneous electric field electrophoresis. The study results suggest mobilization of the beta-lactamase determinant.

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页码：1187 / 1189

页数：3

相关论文

共 25 条

[1] CHARACTERIZATION OF 3 PLASMID DEOXYRIBONUCLEIC-ACID MOLECULES IN A STRAIN OF STREPTOCOCCUS-FAECALIS - IDENTIFICATION OF A PLASMID DETERMINING ERYTHROMYCIN RESISTANCE [J].

CLEWELL, DB ;

YAGI, Y ;

DUNNY, GM ;

SCHULTZ, SK .

JOURNAL OF BACTERIOLOGY, 1974, 117 (01) :283-289

[2]

CLEWELL DB, 1982, J BACTERIOL, V152, P1220

[3] MOLECULAR TYPING OF AMPICILLIN-RESISTANT, NON-BETA-LACTAMASE-PRODUCING ENTEROCOCCUS-FAECIUM ISOLATES FROM DIVERSE GEOGRAPHIC AREAS [J].

DONABEDIAN, SM ;

CHOW, JW ;

BOYCE, JM ;

MCCABE, RE ;

MARKOWITZ, SM ;

COUDRON, PE ;

KURITZA, A ;

PIERSON, CL ;

ZERVOS, MJ .

JOURNAL OF CLINICAL MICROBIOLOGY, 1992, 30 (11) :2757-2761

[4] NUCLEOTIDE-SEQUENCE ANALYSIS OF THE GENE SPECIFYING THE BIFUNCTIONAL 6'-AMINOGLYCOSIDE ACETYLTRANSFERASE 2''-AMINOGLYCOSIDE PHOSPHOTRANSFERASE ENZYME IN STREPTOCOCCUS-FAECALIS AND IDENTIFICATION AND CLONING OF GENE REGIONS SPECIFYING THE 2 ACTIVITIES [J].

FERRETTI, JJ ;

GILMORE, KS ;

COURVALIN, P .

JOURNAL OF BACTERIOLOGY, 1986, 167 (02) :631-638

[5] TRANSFER OF RESISTANCE PLASMIDS FROM STAPHYLOCOCCUS-EPIDERMIDIS TO STAPHYLOCOCCUS-AUREUS - EVIDENCE FOR CONJUGATIVE EXCHANGE OF RESISTANCE [J].

FORBES, BA ;

SCHABERG, DR .

JOURNAL OF BACTERIOLOGY, 1983, 153 (02) :627-634

[6] ANTIMICROBIAL SUSCEPTIBILITY AND MOLECULAR EPIDEMIOLOGY OF BETA-LACTAMASE-PRODUCING, AMINOGLYCOSIDE-RESISTANT ISOLATES OF ENTEROCOCCUS-FAECALIS [J].

MARKOWITZ, SM ;

WELLS, VD ;

WILLIAMS, DS ;

STUART, CG ;

COUDRON, PE ;

WONG, ES .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1991, 35 (06) :1075-1080

[7]

MCLAUGHLIN JR, 1981, J BIOL CHEM, V256, P1283

[8] COMPARISON OF 2 BETA-LACTAMASE-PRODUCING STRAINS OF STREPTOCOCCUS-FAECALIS [J].

MURRAY, BE ;

CHURCH, DA ;

WANGER, A ;

ZSCHECK, K ;

LEVISON, ME ;

INGERMAN, MJ ;

ABRUTYN, E ;

MEDERSKISAMORAJ, B .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 30 (06) :861-864

[9] COMPARISON OF GENOMIC DNAS OF DIFFERENT ENTEROCOCCAL ISOLATES USING RESTRICTION ENDONUCLEASES WITH INFREQUENT RECOGNITION SITES [J].

MURRAY, BE ;

SINGH, KV ;

HEATH, JD ;

SHARMA, BR ;

WEINSTOCK, GM .

JOURNAL OF CLINICAL MICROBIOLOGY, 1990, 28 (09) :2059-2063

[10] BETA-LACTAMASE-PRODUCING ENTEROCOCCI [J].

MURRAY, BE .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (11) :2355-2359