RECOMBINANT GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR MODULATES IN-VITRO FUNCTION OF THE PERIPHERAL-BLOOD MONONUCLEAR-CELLS IN LIPOID NEPHROSIS

被引:1
作者
MATSUMOTO, K
YASUGI, T
机构
[1] Second Dept of Internal Medicine, Nihon University School of Medicine, Itabashi-ku, Tokyo 173
关键词
LIPOID NEPHROSIS; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; INTERLEUKIN-1; LYMPHOCYTE PROLIFERATION;
D O I
10.1159/000168598
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The effect of recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) on the in vitro proliferation of peripheral blood lymphocytes (PBL) was evaluated in patients with lipoid nephrosis (LN). The cytokine increased the proliferation of LN PBL in response to phytohemagglutinin (PHA), measured by the [H-3]thymidine uptake. The effects were abrogated by antibody against human GM-CSF. We then investigated the effect of GM-CSF on the release of interleukin-1 (IL-1) from peripheral blood monocytes (PBM) in LN patients and normals. In vitro IL-1 production by LN PBM treated with lipopolysaccharide (LPS) was enhanced by coculture with GM-CSF. Potentiation was approximately 2-fold. The immunological identity of the thymocyte comitogenic activity as IL-1 was confirmed by neutralization with a specific rabbit antihuman IL-1 antiserum. Taken together, these observations suggest that one mechanism by which GM-CSF acts to restore immune responses in LN patients may be enhancing the signals which enable activated monocytes/macrophages to secrete IL-1.
引用
收藏
页码:100 / 106
页数:7
相关论文
共 11 条
  • [1] GEISSLER K, 1989, J IMMUNOL, V143, P140
  • [2] DEXAMETHASONE INHIBITION OF INTERLEUKIN-1 BETA-PRODUCTION BY HUMAN-MONOCYTES - POSTTRANSCRIPTIONAL MECHANISMS
    KERN, JA
    LAMB, RJ
    REED, JC
    DANIELE, RP
    NOWELL, PC
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1988, 81 (01) : 237 - 244
  • [3] MATSUMOTO K, 1989, CLIN NEPHROL, V31, P292
  • [4] DEFECTIVE CELL-MEDIATED-IMMUNITY IN LIPOID NEPHROSIS
    MATSUMOTO, K
    OSAKABE, K
    KATAYAMA, H
    OKANO, K
    HATANO, M
    [J]. INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1984, 73 (04): : 370 - 372
  • [5] MATSUMOTO K, 1985, J CLIN LAB IMMUNOL, V17, P137
  • [6] MATSUMOTO K, 1985, CLIN NEPHROL, V24, P279
  • [7] MIOSSEC P, 1986, J IMMUNOL, V136, P2486
  • [8] MIZEL SB, 1978, J IMMUNOL, V120, P1497
  • [9] NAKATA K, 1991, J IMMUNOL, V147, P1266
  • [10] STEROID-SENSITIVE MECHANISM OF SOLUBLE IMMUNE-RESPONSE SUPPRESSOR PRODUCTION IN STEROID-RESPONSIVE NEPHROTIC SYNDROME
    SCHNAPER, HW
    AUNE, TM
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1987, 79 (01) : 257 - 264