TAXOL ENCAPSULATION IN POLY(EPSILON-CAPROLACTONE) MICROSPHERES

被引：76

作者：

DORDUNOO, SK

JACKSON, JK

ARSENAULT, LA

OKTABA, AMC

HUNTER, WL

BURT, HM

机构：

[1] UNIV BRITISH COLUMBIA,FAC PHARMACEUT SCI,VANCOUVER,BC V6T 1Z3,CANADA

[2] MCMASTER UNIV,DEPT PATHOL,HAMILTON,ON,CANADA

[3] ANGIOGENESIS TECHNOL INC,VANCOUVER,BC,CANADA

来源：

CANCER CHEMOTHERAPY AND PHARMACOLOGY | 1995年 / 36卷 / 04期

关键词：

TAXOL; MICROSPHERES; ANTIANGIOGENESIS;

D O I：

10.1007/s002800050323

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Poly(epsilon-caprolactone) (PCL) microspheres containing taxol were prepared by the solvent evaporation method and tested for angiogenesis inhibition using the chick chorioallantoic membrane (CAM) model. Very high encapsulation efficiencies (95%) for taxol in PCL microspheres were obtained. In vitro release studies showed about 25% of the loaded drug was released in 6 weeks from microspheres containing 5% taxol. Studies with the CAM showed that taxol released from the microspheres induced vascular regression and inhibited angiogenesis.

引用

页码：279 / 282

页数：4

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