NUCLEAR-CHANGES IN APOPTOSIS

被引：490

作者：

EARNSHAW, WC

机构：

[1] WC Earnshaw, Department of Cell Biology and Anatomy, Johns Hopkins University School of Medicine, Baltimore, MD 21205

来源：

CURRENT OPINION IN CELL BIOLOGY | 1995年 / 7卷 / 03期

关键词：

D O I：

10.1016/0955-0674(95)80088-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Specific proteinases of the Ced-3/interleukin-1 beta converting enzyme family trigger a multi-enzyme cascade that drives apoptotic events. Studies with newly developed cell-free systems have begun to identify the substrates of these and other proteinases in apoptosis. Studies with intact cells have revealed that cleavage of the genome into domain-sized fragments precedes the activation of a second nuclease that fragments the DNA into nucleosome-sized pieces.

引用

页码：337 / 343

页数：7

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