RAT DOPAMINE HYPERSENSITIVITY .1. EFFECT OF AGE

被引：9

作者：

FLEMENBAUM, A ^{[1
]}

机构：

[1] TEXAS TECH UNIV,SCH MED,DEPT PSYCHIAT,LUBBOCK,TX 79409

来源：

NEUROPSYCHOBIOLOGY | 1979年 / 5卷 / 04期

关键词：

D O I：

10.1159/000117685

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Two groups of 5 Sprague-Dawley rats were tested with either d-amphetamine or saline following our drug abuse-kindling model for dopaminergic hypersensitivity on pretest and posttest. However, when the animals were 40 weeks older, the saline group also received d-amphetamine. Thus, this group served as saline control for the initial two tests and as d-amphetamine control for age on the third session. The control group showed significantly more stereotyped behavior on Phase 3 as compared with the experimental group in the first session. These results suggest an increased responsivity of dopaminergic receptors with age as measured by stereotyped behavior in rats.

引用

页码：213 / 221

页数：9

共 38 条

[1] ADRENERGIC-RECEPTOR BLOCKING-AGENTS - EFFECTS ON CENTRAL NORADRENALINE AND DOPAMINE RECEPTORS AND ON MOTOR ACTIVITY [J].

ANDEN, NE ;

STROMBOM, U .

PSYCHOPHARMACOLOGIA, 1974, 38 (02) :91-103

[2]

BURT DR, 1976, SCIENCE, V196, P326

[3] ROLE OF TELENCEPHALIC DOPAMINERGIC SYSTEMS IN MEDIATION OF APOMORPHINE-STEREOTYPED BEHAVIOR [J].

COSTALL, B ;

NAYLOR, RJ .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1973, 24 (01) :8-24

[4] INVOLVEMENT OF DOPAMINERGIC SYSTEMS WITH STEREOTYPED BEHAVIOR PATTERNS INDUCED BY METHYLPHENIDATE [J].

COSTALL, B ;

NAYLOR, RJ .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1974, 26 (01) :30-33

[5] DOPAMINE RECEPTOR-BINDING PREDICTS CLINICAL AND PHARMACOLOGICAL POTENCIES OF ANTI-SCHIZOPHRENIC DRUGS [J].

CREESE, I ;

BURT, DR ;

SNYDER, SH .

SCIENCE, 1976, 192 (4238) :481-483

[6] ROLE OF FOREBRAIN DOPAMINE SYSTEMS IN AMPHETAMINE INDUCED STEREOTYPED BEHAVIOR IN RAT [J].

CREESE, I ;

IVERSEN, SD .

PSYCHOPHARMACOLOGIA, 1974, 39 (04) :345-357

[7] DOPAMINE RECEPTOR-BINDING - DIFFERENTIATION OF AGONIST AND ANTAGONIST STATES WITH H-3-DOPAMINE AND HALOPERIDOL-H-3 [J].

CREESE, I ;

BURT, DR ;

SNYDER, SH .

LIFE SCIENCES, 1975, 17 (06) :993-1001

[8] PHARMACOLOGICAL AND ANATOMICAL SUBSTRATES OF AMPHETAMINE RESPONSE IN RAT [J].

CREESE, I ;

IVERSEN, SD .

BRAIN RESEARCH, 1975, 83 (03) :419-436

[9] DOPAMINE RECEPTOR-BINDING ENHANCEMENT ACCOMPANIES LESION-INDUCED BEHAVIORAL SUPERSENSITIVITY [J].

CREESE, I ;

BURT, DR ;

SNYDER, SH .

SCIENCE, 1977, 197 (4303) :596-598

[10]

ELLINWOOD EH, 1975, BIOL PSYCHIAT, V10, P3

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