DIFFERENTIAL-EFFECTS OF RO 20-1724 AND ISOBUTYLMETHYLXANTHINE ON THE BASAL FORCE OF CONTRACTION AND BETA-ADRENOCEPTOR-MEDIATED RESPONSE IN THE RAT VENTRICULAR MYOCARDIUM

被引：33

作者：

KATANO, Y

ENDOH, M

机构：

[1] Department of Pharmacology, Yamagata University School of Medicine, Yamagata

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 167卷 / 01期

关键词：

D O I：

10.1016/0006-291X(90)91739-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effects of Ro 20-1724, a selective inhibitor of soluble cGMP-insensitive type IV phosphodiesterase, on the force and cAMP levels were compared with those of 3-isobutyl-1-methylxanthine, a non-selective inhibitor, in the rat ventricular myocardium. Ro 20-1724 scarcely affected the basal force of contraction and cAMP levels, whereas it enhanced the positive inotropic effect and cAMP accumulation induced by isoproterenol more effectively than 3-isobutyl-1-methylxanthine. These results imply that inhibition of the soluble cGMP-insensitive type IV PDE by Ro 20-1724 may be crucially involved in the regulation of myocardial contractility through the interaction with cAMP generation in the rat ventricular myocardium. © 1990.

引用

页码：123 / 129

页数：7

共 15 条

[1] INCREASE OF CYCLIC-AMP IN SUBCELLULAR-FRACTIONS OF RAT-HEART MUSCLE AFTER BETA-ADRENERGIC STIMULATION - PRENALTEROL AND ISOPRENALINE CAUSED DIFFERENT DISTRIBUTION OF BOUND CYCLIC-AMP [J].