DEVELOPMENT OF IMMUNOLOGICAL MEMORY IN RAINBOW-TROUT (ONCORHYNCHUS-MYKISS) .1. AN IMMUNOCHEMICAL AND CELLULAR ANALYSIS OF THE B-CELL RESPONSE

被引:63
作者
ARKOOSH, MR [1 ]
KAATTARI, SL [1 ]
机构
[1] OREGON STATE UNIV,DEPT MICROBIOL,CORVALLIS,OR 97331
关键词
IMMUNOLOGICAL MEMORY; FINE SPECIFICITY; RAINBOW TROUT; AFFINITY; LIMITING DILUTION ANALYSIS; ELISA; CLONE SIZE; PRECURSOR FREQUENCY;
D O I
10.1016/0145-305X(91)90021-P
中图分类号
S9 [水产、渔业];
学科分类号
0908 ;
摘要
In vivo and in vitro analyses of the antibody responses of rainbow trout (Oncorhynchus mykiss) confirmed the existence of immunological memory in this species. An enhanced in vitro secondary antibody response was found to be due strictly to an expansion of the antigen-sensitive precursor pool without a concomitant increase in clone size. In contrast to the development of immunological memory in mammalian species, there was no evidence for affinity maturation during the primary or secondary response. A distinct shift in the fine specificity profiles of the antibodies, however, did occur during the generation of the secondary response. Additionally, more than a single injection of the priming antigen, TNP-KLH was required to produce an enhanced in vitro response to this T-dependent antigen. However, a second priming injection was not required to produce an enhanced secondary response to the T-independent form of antigen, TNP-LPS. These results indicate that memory in trout may be due to a simple expansion of the antigen-specific precursor pool without many of the qualitative changes in antibody or B cell function associated with the expression of memory in mammals.
引用
收藏
页码:279 / 293
页数:15
相关论文
共 44 条
[1]   TIMING, GENETIC REQUIREMENTS AND FUNCTIONAL CONSEQUENCES OF SOMATIC HYPERMUTATION DURING B-CELL DEVELOPMENT [J].
ALLEN, D ;
CUMANO, A ;
DILDROP, R ;
KOCKS, C ;
RAJEWSKY, K ;
RAJEWSKY, N ;
ROES, J ;
SABLITZKY, F ;
SIEKEVITZ, M .
IMMUNOLOGICAL REVIEWS, 1987, 96 :5-22
[2]   ANTI-DNP ANTIBODIES IN CARPS AND TORTOISES [J].
AMBROSIUS, H ;
FRENZEL, EM .
IMMUNOCHEMISTRY, 1972, 9 (01) :65-+
[3]  
ARKOOSH MR, 1990, TECHNIQUES FISH IMMU, P15
[4]  
AVTALION RR, 1969, IMMUNOLOGY, V17, P927
[5]   MOLECULAR EVENTS DURING MATURATION OF THE IMMUNE-RESPONSE TO OXAZOLONE [J].
BEREK, C ;
GRIFFITHS, GM ;
MILSTEIN, C .
NATURE, 1985, 316 (6027) :412-418
[6]  
BROOKS KH, 1981, J IMMUNOL, V127, P959
[7]  
CHANG SP, 1982, J IMMUNOL, V129, P1559
[8]   PHYLOGENY OF IMMUNOGLOBULIN STRUCTURE AND FUNCTION .5. VALENCES AND ASSOCIATION CONSTANTS OF TELEOST ANTIBODIES TO A HAPTENIC DETERMINANT [J].
CLEM, LW ;
SMALL, PA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1970, 132 (03) :385-&
[9]  
CLEM LW, 1965, FED PROC, V24, P504
[10]   VARIABILITY IN HUMORAL RESPONSES TO DNP-KLH OF RAINBOW-TROUT (SALMO-GAIRONERI) - COMPARISON OF ANTIBODY KINETICS AND IMMUNOGLOBULINS SPECTROTYPES BETWEEN NORMAL TROUTS AND TROUTS OBTAINED BY GYNOGENESIS OR SELF-FERTILIZATION [J].
COSSARINIDUNIER, M ;
DESVAUX, FX ;
DORSON, M .
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 1986, 10 (02) :207-217