GENETIC-HETEROGENEITY OF THE HUMAN GLUTATHIONE TRANSFERASES - A COMPLEX OF GENE FAMILIES

被引：252

作者：

BOARD, P ^{[1
]}

COGGAN, M ^{[1
]}

JOHNSTON, P ^{[1
]}

ROSS, V ^{[1
]}

SUZUKI, T ^{[1
]}

WEBB, G ^{[1
]}

机构：

[1] QUEEN ELIZABETH HOSP, DEPT GENET, ADELAIDE, SA, AUSTRALIA

来源：

PHARMACOLOGY & THERAPEUTICS | 1990年 / 48卷 / 03期

关键词：

D O I：

10.1016/0163-7258(90)90054-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The glutathione transferases (GSTs) are involved in the metabolism of a wide range of compounds of both exogenous and endogenous origin. There is evidence that deficiency of GST may increase sensitivity to certain environmentally derived carcinogens. In contrast, elevated expression has been implicated in resistance to therapeutic drugs. The GSTs are the products of several gene families. This review summarizes the present knowledge of the genetic interrelationship between the various isoenzymes, their deficiencies and the physical locations of their genes.

引用

页码：357 / 369

页数：13

共 88 条

[1] IMMUNOHISTOCHEMICAL LOCALIZATION OF HUMAN-LIVER GLUTATHIONE S-TRANSFERASE (GST) ISOZYMES WITH SPECIAL REFERENCE TO POLYMORPHIC GST1
ABEI, M
HARADA, S
TANAKA, N
MCNEIL, M
OSUGA, T
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 995 (03) : 279 - 284
[2] GLUTATHIONE TRANSFERASE ISOENZYMES FROM HUMAN TESTIS
ACETO, A
DIILIO, C
ANGELUCCI, S
FELACO, M
FEDERICI, G
[J]. BIOCHEMICAL PHARMACOLOGY, 1989, 38 (21) : 3653 - +
[3] ADACHI Y, 1987, Gastroenterologia Japonica, V22, P34
[4] AKIYAMA K, 1984, JPN J HUM GENET, V29, P271
[5] STRUCTURAL EVIDENCE FOR 3 DIFFERENT TYPES OF GLUTATHIONE TRANSFERASE IN HUMAN-TISSUES
ALIN, P
MANNERVIK, B
JORNVALL, H
[J]. FEBS LETTERS, 1985, 182 (02): : 319 - 322
[6] ERYTHROCYTE GLUTATHIONE SYNTHETASE DEFICIENCY LEADS NOT ONLY TO GLUTATHIONE BUT ALSO TO GLUTATHIONE-S-TRANSFERASE DEFICIENCY
BEUTLER, E
GELBART, T
PEGELOW, C
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1986, 77 (01) : 38 - 41
[7] BEUTLER E, 1988, BLOOD, V72, P73
[8] BHARGAVA MM, 1978, J BIOL CHEM, V253, P4112
[9] BOARD PG, 1981, AM J HUM GENET, V33, P36
[10] ISOLATION OF A CDNA CLONE AND LOCALIZATION OF THE HUMAN GLUTATHIONE S-TRANSFERASE 3-GENES TO CHROMOSOME BANDS 11Q13 AND 12Q13-14
BOARD, PG
WEBB, GC
COGGAN, M
[J]. ANNALS OF HUMAN GENETICS, 1989, 53 : 205 - 213

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