INTRAVENTRICULAR INTERFERON AND ORAL INOSIPLEX IN THE TREATMENT OF SUBACUTE SCLEROSING PANENCEPHALITIS

被引：102

作者：

YALAZ, K ^{[1
]}

ANLAR, B ^{[1
]}

OKTEM, F ^{[1
]}

AYSUN, S ^{[1
]}

USTACELEBI, S ^{[1
]}

GURCAY, O ^{[1
]}

GUCUYENER, K ^{[1
]}

RENDA, Y ^{[1
]}

机构：

[1] HACETTEPE UNIV, DEPT PEDIAT NEUROL, ANKARA, TURKEY

来源：

NEUROLOGY | 1992年 / 42卷 / 03期

关键词：

D O I：

10.1212/WNL.42.3.488

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We treated 22 patients with subacute sclerosing panencephalitis (SSPE) with intraventricular alpha-interferon (IFN) and inosiplex PO and followed them for 2 to 54 months. Three deaths occurred. Clinical improvement, demonstrated by decreasing scores on the Neurological Disability Index, occurred in 11/22 (50%); five patients became stable, and the progression rate of the disease decreased in three. The remission rate was significantly higher than untreated controls from the same institution. Patients who had a slowly progressive disease responded best to treatment. Serious side effects were rare. We recommend intraventricular IFN, combined with oral inosiplex, in the treatment of SSPE.

引用

页码：488 / 491

页数：4

共 27 条

[1]

BYE A, 1985, DEV MED CHILD NEUROL, V27, P170

[2] IDENTIFICATION OF A NONPRODUCTIVE, CELL-ASSOCIATED FORM OF MEASLES-VIRUS BY ITS RESISTANCE TO INHIBITION BY RECOMBINANT HUMAN INTERFERON [J].