6-DEOXYCLITORIACETAL FROM CLITORIA-MACROPHYLLA

被引：32

作者：

LIN, LJ

RUANGRUNGSI, N

CORDELL, GA

SHIEH, HL

MIN, Y

PEZZUTO, JM

机构：

[1] UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,PROGRAM COLLABORAT RES PHARMACEUT SCI,CHICAGO,IL 60612

[2] CHULALONGKORN UNIV,FAC PHARMACEUT SCI,DEPT PHARMACOGNOSY,BANGKOK 10330,THAILAND

来源：

PHYTOCHEMISTRY | 1992年 / 31卷 / 12期

关键词：

CLITORIA-MACROPHYLLA; LEGUMINOSAE; ROOTS; 12A-HYDROXYROTENOID; 6-DEOXYCLITORIACETAL; COLOC NMR SPECTROSCOPY; CYTOTOXIC ACTIVITY;

D O I：

10.1016/0031-9422(92)80468-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new rotenoid, 6-deoxyclitoriacetal, was isolated from the roots of Clitoria macrophylla and its structural assignment was established unambiguously by a series of HETCOR, COLOC and NOE difference experiments. In vitro tests showed that this compound possessed strong cytotoxic activity against cultured P-388 lymphocytic leukemia cells, but was not active with cultured KB cells. However, marginal activity was observed with vinblastine-resistant KB-V1 cells, and this was enhanced by the addition of vinblastine. This rotenoid may, therefore, interact with P-glycoprotein.

引用

页码：4329 / 4331

页数：3

共 6 条

[1] PROTON MAGNETIC STUDIES OF ROTENONE AND RELATED COMPOUNDS [J].