A METHOD TO INCREASE THE CUMULATIVE CLEAVAGE EFFICIENCY OF RIBOZYMES - THERMAL CYCLING

被引：10

作者：

DROPULIC, B ^{[1
]}

LIN, NH ^{[1
]}

JEANG, KT ^{[1
]}

机构：

[1] NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892

来源：

NUCLEIC ACIDS RESEARCH | 1993年 / 21卷 / 09期

关键词：

D O I：

10.1093/nar/21.9.2273

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：2273 / 2274

页数：2

共 9 条

[1] DIRECTED EVOLUTION OF AN RNA ENZYME [J].

BEAUDRY, AA ;

JOYCE, GF .

SCIENCE, 1992, 257 (5070) :635-641

[2] INVITRO SELECTION OF ACTIVE HAIRPIN RIBOZYMES BY SEQUENTIAL RNA-CATALYZED CLEAVAGE AND LIGATION REACTIONS [J].

BERZALHERRANZ, A ;

JOSEPH, S ;

BURKE, JM .

GENES & DEVELOPMENT, 1992, 6 (01) :129-134

[3] MULTITARGET-RIBOZYME DIRECTED TO CLEAVE AT UP TO 9 HIGHLY CONSERVED HIV-1 ENV RNA REGIONS INHIBITS HIV-1 REPLICATION POTENTIAL EFFECTIVENESS AGAINST MOST PRESENTLY SEQUENCED HIV-1 ISOLATES [J].

CHEN, CJ ;

BANERJEA, AC ;

HARMISON, GG ;

HAGLUND, K ;

SCHUBERT, M .

NUCLEIC ACIDS RESEARCH, 1992, 20 (17) :4581-4589

[4]

DROPULIC B, 1992, J VIROL, V66, P1432

[5] SIMPLE RNA ENZYMES WITH NEW AND HIGHLY SPECIFIC ENDORIBONUCLEASE ACTIVITIES [J].

HASELOFF, J ;

GERLACH, WL .

NATURE, 1988, 334 (6183) :585-591

[6] EVOLUTION INVITRO OF AN RNA ENZYME WITH ALTERED METAL DEPENDENCE [J].

LEHMAN, N ;

JOYCE, GF .

NATURE, 1993, 361 (6408) :182-185

[7]

Taylor N R, 1991, Antisense Res Dev, V1, P173

[8] A SMALL CATALYTIC OLIGORIBONUCLEOTIDE [J].

UHLENBECK, OC .

NATURE, 1987, 328 (6131) :596-600

[9] RIBOZYMES WHICH CLEAVE ARENAVIRUS RNAS - IDENTIFICATION OF SUSCEPTIBLE TARGET SITES AND INHIBITION BY TARGET SITE SECONDARY STRUCTURE [J].

XING, Z ;

WHITTON, JL .

JOURNAL OF VIROLOGY, 1992, 66 (03) :1361-1369

← 1 →