THE ROLE OF OXIDATION AND GLYCATION IN THE PATHOGENESIS OF DIABETIC ATHEROSCLEROSIS

被引：17

作者：

OBRIEN, R

TIMMINS, K

机构：

[1] Richard O'Brien and Katrina Timmins are, the Diabetes Unit, Department of Medicine, Clayton

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1994年 / 5卷 / 08期

关键词：

D O I：

10.1016/1043-2760(94)90162-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes carries an increased risk of atherosclerotic disease that is not fully explained by known cardiovascular risk factors. There is accumulating evidence that advanced glycation of structural proteins, and oxidation and glycation of circullating lipoproteins, are implicated in the pathogenesis of diabetic atherosclerosis. Antioxidants can inhibit oxidation and advanced glycation in vitro, and antioxidant therapy can prevent cardiovascular disease in nondiabetic individuals. Large-scale clinical studies are required to determine the therapeutic role of antioxidants and specific antiglycation agents in diabetic vascular disease.

引用

页码：329 / 334

页数：6

共 77 条

[1] PROTECTIVE EFFECT OF VITAMIN-E SUPPLEMENTATION ON INCREASED THERMAL-STABILITY OF COLLAGEN IN DIABETIC RATS [J].