ATP AND ADENYLATE ENERGY-CHARGE DURING PHOSPHATE-MEDIATED CONTROL OF ANTIBIOTIC SYNTHESIS

被引：34

作者：

MARTIN, JF ^{[1
]}

LIRAS, P ^{[1
]}

DEMAIN, AL ^{[1
]}

机构：

[1] MIT,DEPT NUTR & FOOD SCI,CAMBRIDGE,MA 02139

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1978年 / 83卷 / 03期

关键词：

D O I：

10.1016/0006-291X(78)91468-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The addition of inorganic phosphate or guanosine-5′-monophosphate to a phosphate-limited mycelial system of Streptomyces griseus inhibited candicidin production. Accompanying the inhibition was a rapid increase in intracellular ATP concentration. Adenylate energy charge increased only slightly indicating that ATP is a more likely intracellular effector than energy charge in mediating phosphate control of antibiotic biosynthesis. © 1978.

引用

页码：822 / 828

页数：7

共 20 条

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