GLUTATHIONE .4. INTRACELLULAR OXIDATION AND MEMBRANE INJURY

被引：71

作者：

KOSOWER, NS

SONG, KR

KOSOWER, EM

机构：

[1] Department of Medicine, Albert Einstein College of Medicine, Yeshiva University, Bronx

[2] Department of Chemistry, State University of New York at Stony Brook, Stony Brook

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1969年 / 192卷 / 01期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/0304-4165(69)90005-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. 1. Incubation of erythrocytes containing carbon monoxide hemoglobin at 37° is oxygenated isotonic buffer after treatment with azoester at 1° leads to hemolysis in vitro. 2. 2. Hemolysis is only observed after the use of quantities of azoester greater than that required to oxidize all the intracellular GSH to GSSG. 3. 3. Hemolysis is explained as the consequence of membrane damage produced by the free radicals generated by excess azoester. 4. 4. Membrane damage occurs in the absence of GSH and leads to cell lysis. We term the phenomenon the GSH loss catastrophe". © 1969."

引用

页码：23 / &

共 17 条

[1] OXIDATIVE HEMOLYSIS AND PRECIPITATION OF HEMOGLOBIN .2. ROLE OF THIOLS IN OXIDANT DRUG ACTION [J].