HYPOGLYCEMIC EFFECT OF SWERCHIRIN FROM THE HEXANE FRACTION OF SWERTIA-CHIRAYITA

被引：67

作者：

BAJPAI, MB ^{[1
]}

ASTHANA, RK ^{[1
]}

SHARMA, NK ^{[1
]}

CHATTERJEE, SK ^{[1
]}

MUKHERJEE, SK ^{[1
]}

机构：

[1] CENT DRUG RES INST, LUCKNOW 226001, UTTAR PRADESH, INDIA

来源：

PLANTA MEDICA | 1991年 / 57卷 / 02期

关键词：

SWERTIA-CHIRAYITA; SWERCHIRIN; HYPOGLYCEMIA;

D O I：

10.1055/s-2006-960041

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A xanthone was isolated from the hexane fraction of the Swertia chirayita plant and identified as 1,8-dihydroxy-3,5-dimethoxyxanthone (swerchirin). It has a very significant blood sugar lowering effect in fasted, fed, glucose loaded, and tolbutamide pretreated albino rat models. The ED50 for 40% blood sugar lowering in CF male albino rats (body weight 140-165 g) is 23.1 mg/kg/oral. The possibility of its application in clinical therapy for diabetes mellitus needs exploration.

引用

页码：102 / 104

页数：3

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