CALCIFEROL AND ITS RELATIVES .24. SYNTHESIS OF VITAMIN-D4

被引：61

作者：

KOCIENSKI, PJ ^{[1
]}

LYTHGOE, B ^{[1
]}

机构：

[1] UNIV LEEDS,DEPT ORGAN CHEM,LEEDS LS2 9JT,W YORKSHIRE,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1979年 / 05期

关键词：

D O I：

10.1039/p19790001290

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

8α-Phenylsulphonyl-des-AB-ergostane (16),†,‡ prepared from des-AB-ergost-8-ene, formed a lithium derivative which reacted with the benzoyloxy-aldehyde (8) † to give, after treatment with trimethylchlorosilane, a mixture of β-silyloxy-sulphones. Reduction with lithium amalgam, followed by removal of the benzoyl group, gave vitamin D 4 (2).

引用

页码：1290 / 1293

页数：4

共 14 条

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[8] CALCIFEROL AND ITS RELATIVES .15. PREPARATION OF DES-AB-CHOLEST-8-ENE-8-CARBALDEHYDE [1BETA-[(1R)-1,5-DIMETHYLHEXYL]-3AALPHA,6,7,7ABETA-TETRAHYDRO-7ABETA-METHYLINDANE-4-CARBALDEHYDE] AND 9ALPHA-CHLORO-DES-AB-CHOLESTAN-8-ONE [5ALPHA-CHLORO-1BETA-[(1R)-1,5-DIMETHYLHEXYL]-7ABETA-METHYL-TRANS-PERHYDROINDAN-4-ONE] [J].

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