REGULATION OF THE STATE OF PHOSPHORYLATION OF SPECIFIC NEURONAL PROTEINS IN MOUSE-BRAIN BY INVIVO ADMINISTRATION OF ANESTHETIC AND CONVULSANT AGENTS

被引：42

作者：

STROMBOM, U ^{[1
]}

FORN, J ^{[1
]}

DOLPHIN, AC ^{[1
]}

GREENGARD, P ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,DEPT PHARMACOL,NEW HAVEN,CT 06510

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 09期

关键词：

D O I：

10.1073/pnas.76.9.4687

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The effect of drug treatment in vivo on the state of phosphorylation of 2 specific neuronal proteins, proteins Ia and Ib, has been studied in mouse brain. For this purpose, animals were killed by immersion into liquid nitrogen, and proteins Ia and Ib were extracted by a procedure designed to prevent alterations in their state of phosphorylation. Several anesthetic agents (pentobarbital, chloral hydrate, and urethane) each caused a decrease in the state of phosphorylation of these proteins. Conversely, the convulsant agents pentylenetetrazol and picrotoxin each caused an increase in the state of phosphorylation of these proteins. Neither the anesthetic nor the convulsant agents affected the total amount of these proteins. The results are compatible with a role for proteins Ia and Ib in neuronal function.

引用

页码：4687 / 4690

页数：4

共 18 条

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