CORRECTABLE SUBSETS OF PRIMARY ALDOSTERONISM - PRIMARY ADRENAL-HYPERPLASIA AND RENIN RESPONSIVE ADENOMA

被引：146

作者：

IRONY, I ^{[1
]}

KATER, CE ^{[1
]}

BIGLIERI, EG ^{[1
]}

SHACKLETON, CHL ^{[1
]}

机构：

[1] SAN FRANCISCO GEN HOSP,MED CTR,CTR CLIN STUDY,BLDG 100,ROOM 321,1001 POTRERO AVE,SAN FRANCISCO,CA 94110

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 07期

关键词：

Hyperaldosteronism; Hypertension; Mineralocorticoids; Primary adrenal hyperplasia; Renin responsive adenoma;

D O I：

10.1093/ajh/3.7.576

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Among 154 cases of primary aldosteronism seen in the General Clinical Research Center at San Francisco General Hospital, twelve patients did not fulfill established characteristics of an aldosterone producing adenoma (APA) or idiopathic hyperaldosteronism (IHA). Eight patients had nodular adrenocortical hyperplasia; plasma and urinary aldosterone were elevated and responses to stimulatory and suppressive maneuvers demonstrated the same autonomy seen in patients with APA. This subset is designated primary adrenal hyperplasia. Four additional patients also had elevated aldosterone levels that were responsive to these maneuvers, similar to IHA, but had unilateral tumors. This group has been designated as aldosterone-producing renin-responsive adenoma. Eleven patients had unilateral adrenalectomy and one preferred prolonged spironolactone therapy, resulting in a sustained cure or amelioration of hypertension, hypokalemia and normalization of aldosterone production. © 1990 by the American Journal of Hypertension, Ltd.

引用

页码：576 / 582

页数：7

共 18 条

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