ANTITUMOR-ACTIVITY IN SKIN OF SKH AND SENCAR MICE BY 2 DIETARY BETA-CAROTENE FORMULATIONS

被引：36

作者：

LAMBERT, LA

KOCH, WH

WAMER, WG

KORNHAUSER, A

机构：

[1] Division of Toxicology, Center for Food Safety and Applied Nutrition, US Food and Drug Administration, Washington

来源：

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 1990年 / 13卷 / 04期

关键词：

D O I：

10.1080/01635589009514063

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

There is currently a great interest in the protective potential of -carotene and other micronutrients against carcinogenesis. We investigated the role of 0-carotene in modifying 7, 12-dimethylbenzfaJanthracene (DMBAf initiated, 12-0-tetradecanoylphorbol-13-acetate (TPA)-promoted, two-stage skin carcinogenesis. We were interested in comparing the protective effects of two types of dietary 0-carotene, a beadlet formulation and crystalline 0-carotene, in two strains of mice (Skh:HR-l and CR:ORL Senear). Mice were maintained throughout the study on one of these 3% 0-carotene-fortified diets or on control diets. In Week 11 after the start of the diets, the DMBA/TPA treatment regimen was begun. The resulting skin tumors were counted weekly. In addition, serum and skin levels were monitored for 0-carotene at the time of chemical initiation and at the termination of the study. A decrease in the number of cumulative tumors in the 0-carotene-fed animals compared with the appropriate control groups was observed in both strains of mice. However, statistical evaluation of the data revealed that the decrease was significant only in Skh mice. This phenomenon might be explained by the inherent sensitivity of Senear mice to the two-stage carcinogenesis treatment regimen. The mechanism of the protective effect found in this study is still not clear. Recent data suggest that a vitamin A pathway is not probable but that a direct J0 2and/or radical-quenching property of the parent 0-carotene molecule may be involved. This study also demonstrates that tv>o-stage-induced skin tumorigenesis can be modified by both tvves of B-carotene-fortified diets. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：213 / 221

页数：9

共 17 条

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