SENDAI VIRUS P-GENE PRODUCES MULTIPLE PROTEINS FROM OVERLAPPING OPEN READING FRAMES

被引:32
作者
CURRAN, J [1 ]
KOLAKOFSKY, D [1 ]
机构
[1] UNIV GENEVA,SCH MED,DEPT MICROBIOL,CMU 9 AVE DE CHAMPEL,CH-1211 GENEVA 4,SWITZERLAND
关键词
OPEN READING FRAMES; OVERLAPPING; START CODONS; NON-AUG; SCANNING; MESSENGER RNA; MESSENGER RNA EDITING;
D O I
10.1159/000468762
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The Sendai virus P gene contains overlapping open reading frames (ORFs), and several unusual mechanisms are used to produce multiple proteins from all three ORFs of this gene. These include the use of a non-AUG start codon, leaky ribosomal scanning, what appears to be scanning-independent ribosomal initiation and/or ribosomal jumping, and a form of mRNA editing.
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页码:244 / 249
页数:6
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