CHOLECYSTOKININ SUPPRESSES SHAM FEEDING IN THE RHESUS-MONKEY

被引：76

作者：

FALASCO, JD ^{[1
]}

SMITH, GP ^{[1
]}

GIBBS, J ^{[1
]}

机构：

[1] CORNELL UNIV,MED CTR,DEPT PSYCHIAT,NEW YORK,NY 10021

来源：

PHYSIOLOGY & BEHAVIOR | 1979年 / 23卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Cholecystokinin; Gastric cannula; Pharmacological effect; Physiological effect; Rhesus monkey; Satiety; Satiety behavior; Sham feeding;

D O I：

10.1016/0031-9384(79)90196-3

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The satiety effect of slow intravenous infusions of impure cholecystokinin (CCK) was investigated in 5 rhesus monkeys during sham feeding. CCK suppressed sham feeding. The dose for 50% inhibition of sham feeding was about 10 U/kg-hr; 20 U/kg-hr abolished sham feeding. No dose produced retching, vomiting, diarrhea or other behavioral signs of toxicity. These results demonstrate the potency of CCK for inhibiting feeding in the monkey when gastric, intestinal and postabsorptive mechanisms are not activated by ingested food. © 1979.

引用

页码：887 / 890

页数：4

共 21 条

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