DESIGN, SYNTHESIS AND CHARACTERIZATION OF A 34-RESIDUE POLYPEPTIDE THAT INTERACTS WITH NUCLEIC-ACIDS

被引：97

作者：

GUTTE, B

DAUMIGEN, M

WITTSCHIEBER, E

机构：

[1] Max-Planck-Institut für Biophysikalische Chemie, Abteilung Biochemische Kinetik

来源：

NATURE | 1979年 / 281卷 / 5733期

关键词：

D O I：

10.1038/281650a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Based on secondary structure prediction rules and model building a neutral artificial 34-residue polypeptide with potential nucleic acid-binding activity was synthesised. This peptide and its covalent dimer showed strong interaction with cytidine phosphates and single-stranded DNA. The dimer had considerable ribonuclease activity with high preference for cleavage at the 3'-end of C. © 1979 Nature Publishing Group.

引用

页码：650 / 655

页数：6

共 30 条

[1] ANFINSEN CB, 1954, J BIOL CHEM, V207, P201
[2] COMPLEX OF RIBONUCLEASE WITH A SUBSTRATE ANALOGUE, CYTIDINE 2'-PHOSPHATE
BARNARD, EA
RAMEL, A
[J]. NATURE, 1962, 195 (4838) : 243 - &
[3] AMINO-ACID SEQUENCE OF LAC REPRESSOR
BEYREUTHER, K
ADLER, K
GEISLER, N
KLEMM, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (12) : 3576 - 3580
[4] STRUCTURE OF LIVER ALCOHOL-DEHYDROGENASE AT 2.9-A RESOLUTION
BRANDEN, CI
EKLUND, H
NORDSTROM, B
BOIWE, T
SODERLUND, G
ZEPPEZAUER, E
OHLSSON, I
AKESON, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (08) : 2439 - 2442
[5] BUEHNER M, 1973, P NATL ACAD SCI USA, V70, P3052, DOI 10.1073/pnas.70.11.3052
[6] SYNTHESIS OF A DECAPEPTIDE WITH GLYCOSIDASE ACTIVITY
CHAKRAVARTY, PK
MATHUR, KB
DHAR, MM
[J]. EXPERIENTIA, 1973, 29 (07): : 786 - 788
[7] CONFORMATIONAL PARAMETERS FOR AMINO-ACIDS IN HELICAL, BETA-SHEET, AND RANDOM COIL REGIONS CALCULATED FROM PROTEINS
CHOU, PY
FASMAN, GD
[J]. BIOCHEMISTRY, 1974, 13 (02) : 211 - 222
[8] PREDICTION OF PROTEIN CONFORMATION
CHOU, PY
FASMAN, GD
[J]. BIOCHEMISTRY, 1974, 13 (02) : 222 - 245
[9] BETA-TURNS IN PROTEINS
CHOU, PY
FASMAN, GD
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1977, 115 (02) : 135 - 175
[10] CONFORMATIONAL PREDICTION AND CIRCULAR-DICHROISM STUDIES ON LAC REPRESSOR
CHOU, PY
ADLER, AJ
FASMAN, GD
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1975, 96 (01) : 29 - 45

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