CONFORMATION CONTROL OF BILATRIENES BY PEPTIDES - A SURVEY

被引：8

作者：

KROIS, D ^{[1
]}

LEHNER, H ^{[1
]}

机构：

[1] UNIV VIENNA,INST ORGAN CHEM,A-1090 VIENNA,AUSTRIA

来源：

MONATSHEFTE FUR CHEMIE | 1991年 / 122卷 / 1-2期

关键词：

BILIPEPTIDES; CONFORMATION CONTROL; CHIRAL DISCRIMINATION; BILATRIENES; NON-HELICAL;

D O I：

10.1007/BF00815170

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A variety of bilipeptides has been synthesized and investigated by UV-VIS and CD spectroscopy to explore the conformational influence of peptide ligands on the covalently bound tetrapyrrol moiety. The results obtained are complemented by those reported previously. From the comprehensive data thus available several features of the peptide chain regulating interactions with the bilatriene moiety have been elucidated. Accordingly, the presence of three amide linkages at the ligand is prerequiste for induction of pronounced conformational changes consisting either in a complete transition of M into P helical bilatriene species by inversion of all torsional angles, or in a stretching of the chromophore. The kind of conformational influence can be controlled by varying the position of the prolyl entity within a given peptide.

引用

页码：89 / 100

页数：12

共 13 条

[1] CHIRAL INDUCTION IN BILIVERDIN COVALENTLY BOUND TO AMINO-ACIDS [J].