CHIRAL RECOGNITION BY CHROMATOGRAPHY AND COMPUTATIONAL CHEMISTRY

被引：11

作者：

HANAI, T ^{[1
]}

HATANO, H ^{[1
]}

NIMURA, N ^{[1
]}

KINOSHITA, T ^{[1
]}

机构：

[1] KITASATO UNIV,SCH PHARMACEUT SCI,MINATO KU,TOKYO 108,JAPAN

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1993年 / 16卷 / 04期

关键词：

D O I：

10.1080/10826079308020935

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

After minimization of the energies of individual compounds including a chiral selector using MM2 calculation of CAChe(TM) a pair of molecules was brought together to form a complex, and non-bonded energy was minimized. The energy of R- & S-pairs of alanines and phenylalanines was lower than that of the R- & R- and S- & S-pairs of alanines and phenylalanines. The energy of several pairs of R- & S-N-4-nitrobenzoyl amino acids and a chiral selector, N-butylrylvalinetert-butylamide, also indicated the chiral recognition. The energies of pairs of the selctor and S-amino acids were lower than that of the selector and R-amino acids.

引用

页码：801 / 808

页数：8