ABNORMAL PEPTIDOGLYCAN PRODUCED IN A METHICILLIN-RESISTANT STRAIN OF STAPHYLOCOCCUS-AUREUS GROWN IN THE PRESENCE OF METHICILLIN - FUNCTIONAL-ROLE FOR PENICILLIN-BINDING PROTEIN-2A IN CELL-WALL SYNTHESIS

被引：79

作者：

DEJONGE, BLM ^{[1
]}

TOMASZ, A ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,1230 YORK AVE,NEW YORK,NY 10021

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1993年 / 37卷 / 02期

关键词：

D O I：

10.1128/AAC.37.2.342

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Upon the addition of methicillin even at relatively low concentrations (5 mug/ml or 0.3% of the MIC) to the medium, methicillin-resistant staphylococci shift to the production of a new peptidoglycan with an abnormal muropeptide composition which may be the synthetic product of penicillin-binding protein 2A.

引用

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页码：342 / 346

页数：5

相关论文

共 9 条

[1] BINDING OF BETA-LACTAM ANTIBIOTICS TO PENICILLIN-BINDING PROTEINS IN METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS [J].

CHAMBERS, HF ;

SACHDEVA, M .

JOURNAL OF INFECTIOUS DISEASES, 1990, 161 (06) :1170-1176

[2]

DEJONGE BLM, 1992, J BIOL CHEM, V267, P11248

[3] 2 DISTINCT TRANSPEPTIDATION REACTIONS DURING MUREIN SYNTHESIS IN ESCHERICHIA-COLI [J].

KRAUS, W ;

HOLTJE, JV .

JOURNAL OF BACTERIOLOGY, 1987, 169 (07) :3099-3103

[4] INVOLVEMENT OF MULTIPLE GENETIC-DETERMINANTS IN HIGH-LEVEL METHICILLIN RESISTANCE IN STAPHYLOCOCCUS-AUREUS [J].

MURAKAMI, K ;

TOMASZ, A .

JOURNAL OF BACTERIOLOGY, 1989, 171 (02) :874-879

[5] EFFECTS OF GROWTH OF METHICILLIN-RESISTANT AND METHICILLIN-SUSCEPTIBLE STAPHYLOCOCCUS-AUREUS IN THE PRESENCE OF BETA-LACTAMS ON PEPTIDOGLYCAN STRUCTURE AND SUSCEPTIBILITY TO LYTIC ENZYMES [J].

QORONFLEH, MW ;

WILKINSON, BJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1986, 29 (02) :250-257

[6]

SIDOW T, 1990, ARCH MICROBIOL, V154, P73

[7] CROSS-LINKING AND O-ACETYLATION OF PEPTIDOGLYCAN IN STAPHYLOCOCCUS-AUREUS (STRAIN-H AND STRAIN-MR-1) GROWN IN THE PRESENCE OF SUB-GROWTH-INHIBITORY CONCENTRATIONS OF BETA-LACTAM ANTIBIOTICS [J].

SNOWDEN, MA ;

PERKINS, HR .

JOURNAL OF GENERAL MICROBIOLOGY, 1991, 137 :1661-1666

[8] THE FUNCTIONAL BIOSYNTHESIS OF BACTERIAL-CELL WALL PEPTIDOGLYCAN .3. EVOLUTION OF AN INDUCIBLE PENICILLIN-TARGET PROTEIN IN METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS BY GENE FUSION [J].

SONG, MD ;

WACHI, M ;

DOI, M ;

ISHINO, F ;

MATSUHASHI, M .

FEBS LETTERS, 1987, 221 (01) :167-171

[9] FINE STRUCTURE OF DIPLOCOCCUS PNEUMONIAE [J].

TOMASZ, A ;

JAMIESON, JD ;

OTTOLENGHI, E .

JOURNAL OF CELL BIOLOGY, 1964, 22 (02) :453-&